A dual DNA tetrahedrons and MnO2 nanosheets sustained entropy-driven DNA amplifier enables high-performance operation in live cells and bodies under a light-gated manner

•Dual DNA tetrahedrons are used to sustain an entropy-driven DNA amplifier.•MnO2 nanosheet is employed as an additional delivery vehicle to improve endocytosis.•A light-gated manner is incorporated to achieve an exceptional precise target identification.•The biosensor can work as an high-performance imaging toolbox for operation in live cells and bodies.