Atherosclerotic plaque-targeted nanotherapeutics ameliorates atherogenesis by blocking macrophage-driven inflammation

Hui Yang,Chang Liu,Yanjun Wu,Meng Yuan,Jiarun Huang,Yuhan Xia,Qinjie Ling,Peter R. Hoffmann,Zhi Huang,Tianfeng Chen

Nano Today（2022）

引用 19|浏览13

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摘要

•MSeNP@CIP targets macrophages to treat atherosclerosis.•MSeNP@CIP reduces aortic plaques by protecting ATP-binding cassette transporter against calpain proteolytic cleavage.•MSeNP@CIP can reprogram macrophages to an M2 phenotype to exert anti-inflammatory effects.

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关键词

Atherosclerosis,Macrophage,Calpain,Calpain inhibitory peptide,Selenium nanoparticle,Mannose

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