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CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy

Meng Lin,Zhenzhen Yang,Yiliang Yang,Yiwei Peng,Jiajia Li,Yitian Du, Qi Sun,Datong Gao,Quan Yuan,Yu Zhou,Xinyi Chen,Xianrong Qi

Nano Today（2022）

Cited 24|Views22
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Abstract
•A selective responsiveness accelerated gene delivery system was constructed.•The gene delivery system rendered tumor-specific CD47 knockout and engineered tumor cells into factories of IL-12.•Combination of CD47 blockade and IL-12 production synergistically promoted the macrophage-mediated immunotherapy.
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Key words
CD47 blockade,IL-12 production,Selective responsiveness accelerated gene delivery system,TAM polarization,CRISPR/Cas9
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