Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7 H -furo[2,3-f]chromen-2-yl)(aryl)methanones

A series of (3-methyl-7 H -furo[2,3-]chromen-2-yl)(aryl)methanones were quickly prepared through easily accessible, short-span progress microwave irradiation and conventional heating methods. The structures of these synthesized compounds were confirmed by IR, NMR ( 1 H, 13 C) and mass spectral analysis. Further, the in vitro antiproliferative activities were tested against MCF-7 (human breast adenocarcinoma cells) and C-6 (nerve cells) using the MTT assay. The compounds 5b and 5g a showed better antiproliferative activity than Cisplatin . Additionally, in vitro antibacterial and antifungal activities were carried out against different bacterial and fungal strains. Compounds 5b, 5c and 5g showed a substantial inhibition effect than Ciprofloxacin and Fluconazole standard drugs respectively., UV-Visible and fluorescence measurements were conducted to assess the interaction of the compounds with CT-DNA compounds 5c, 5d , and 5g showed a stronger DNA binding affinity.