Role of Platelet Rich Plasma in Management of Post Acne Scars

Acne is a chronic inflammatory skin disease of the pilosebaceous glands, usually, starts in adolescence and lasting into adulthood, with outbreaks sometimes coinciding with changes in serum androgens. About 85% of teenagers and 40% of adults develop late-onset acne. It is one of the most prevalent dermatological diseases, influenced by genetics and environmental factors.Platelet-rich plasma (PRP) has potential benefits in the treatment of post-acne atrophic scars. PRP contains various growth factors contained in alpha granules and dense granules. Alpha granules contain seven fundamental growth factors: the platelet-derived growth factors (PDGFaa, PDGFbb, and PDGFab), transforming growth factor-beta (TGFb1 and 2), epithelial growth factor (EGF), and vascular endothelial growth factor (VEGF). These growth factors modulate cell proliferation, angiogenesis, and collagen induction which ultimately enhance the remodelling of post-acne atrophic scars.