Synthesis and biological evaluation of polyfluoroalkyl-containing 4-arylhydrazinylidene-isoxazoles as antifungal agents with antioxidant activity

Natalia A. Elkina,Evgeny V. Shchegolkov,Yanina V. Burgart,Natalia A. Agafonova,Anastasia N. Perminova,Natalia A. Gerasimova,Galina F. Makhaeva,Elena V. Rudakova,Nadezhda V. Kovaleva,Natalia P. Boltneva,Olga G. Serebryakova,Sophia S. Borisevich,Natalia P. Evstigneeva,Natalia V. Zilberberg,Nikolai V. Kungurov,Victor I. Saloutin

Journal of Fluorine Chemistry（2022）

引用 3|浏览14

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摘要

•Chemoselective synthesis of polyfluoroalkyl-4-arylhydrazinylidene-isoxazoles•Structural peculiarities of isoxazoles•Promising antimicrobial activity•Antioxidant activity is higher than Trolox one

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关键词

Polyfluoroalkyl-containing 4-arylhydrazinylidene-isoxazoles,Synthesis,Regioisomers,Quantum-chemical calculations,Antifungal,Antibacterial and antioxidant activity,Esterase profile

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