Tertiary Alkylative Suzuki-Miyaura Couplings

Suzuki-Miyaura coupling is an extremely useful way to construct Csp(2)-Csp(2) carbon bonds. On the other hand, Csp(2) -Csp(3) coupling reactions do not work well, and tert-alkylative Suzuki-Miyaura coupling is particularly challenging due to problematic oxidative addition and beta-hydride elimination side reactions. In this short review, we will introduce recent examples of tert-alkylative Suzuki-Miyaura couplings with tert-alkyl electrophiles or -boron reagents. The review will mainly focus on catalyst and product structures and on the proposed mechanisms.