THREE NEW QUINOLINE ALKALOIDS FROM THE WHOLE PLANT OF THALICTRUM ATRIPLEX AND THEIR BIOACTIVITIES

Three new quinoline alkaloids, thalicalkaloids A-C (1-3) together with three known alkaloids were isolated from the whole plant of Thalictrum atriplex. Their structures were elucidated by spectroscopic methods, including extensive H-1, C-13, and 2D-NMR techniques. Compounds 1-6 were tested for their antibacterial and anti-rotavirus activities. The results revealed that compound 3 exhibited high anti-rotavirus activity with therapeutic index (TI) valves of 24.0, and this valve is close to the positive control. Compounds 1, 2, 4-6 also showed potent anti-rotavirus activities with therapeutic index (TI) valves in the range of 11.015.8, respectively. In addition, compounds 1-6 showed good anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activities with IZD of 12.2 +/- 1.5, 15.8 +/- 1.4, 14.5 +/- 1.2, 12.6 +/- 1.2, 13.4 +/- 1.4, and 14.0 +/- 1.5 mm, respectively.