Comparison of the Effects of Orthokeratology Lens and Cyclopentolate on Myopia Progression in Children

Purpose: To compare the effects of orthokeratology lens (Ortho-K lens) and topical cyclopentolate on myopia progression in children. Methods: This retrospective study analyzed the medical records of 36 children who received Ortho-K lens and 28 who received cyclopentolate (i.e., total of 64 eyes). The following data were recorded: sex, age, age at first intervention, follow-up duration, and visual acuity and axial length (AL) at the time of first treatment and after 6, 12, and 24 months of treatment. Results: In the Ortho-K group, the changes of AL significantly decreased by 0.3 +/- 0.25 mm at 12 months and 0.52 +/- 0.34 mm at 24 months (p for trend < 0.001). In the cyclopentolate group, the changes of AL significantly decreased by 0.36 +/- 0.17 mm at 12 months and 0.62 +/- 0.29 mm at 24 months (p for trend = 0.022). Compared to the use of cyclopentolate, the use of Ortho-K lens resulted in smaller changes in AL during follow-up (p = 0.038). Conclusions: In myopic children, Ortho-K reduced myopia progression, whereas cyclopentolate significantly less affect myopia progression than Ortho-K lens.