Features of anemia in pregnant women of various genesis in ethnic samples

In order to study the factors influencing the development of pregnancy, perinatal outcomes in anemia of various genesis in pregnant women, a prospective cohort study of pregnant women with iron deficiency anemia (IDA) and anemia of chronic disease (ACD) in various ethnic samples (in the Republic of Dagestan and in the Republic of Sakha) (Yakutia)) was performed. The study revealed the effect of the activity of compensatory-adaptive mechanisms of the placenta on perinatal outcomes in different genesis of anemia. Pregnant women with IDA were distinguished by a balanced increase in pro- and antioxidant factors. Iron metabolism violations in ACD were accompanied by a pronounced imbalance in the production of hydroperoxides and antioxidant protection factors. The effect of excess lipid peroxidation products on the placenta in ACD in the Yakut population was accompanied by an evolutionarily accumulated level of endogenous antioxidants (blood plasma and erythrocyte catalase, sulfhydryl groups). A decrease in the compensatory mechanisms of the placenta of pregnant Dagestan women with ACD influenced the higher frequency of morphological and functional immaturity of newborns due to the moderate antioxidant potential.