New Cyclic Peptides from the Endophytic Aspergillus versicolor 0312 with Their Antimicrobial Activity

This article aims to investigate the chemical constituents of the endophytic Aspergillus versicolor 0312 cultivated in the solid fermentation of rice perlite. Two new cyclic peptide compounds, 7-hydroxyldehydrocyclopeptin (1), 14,31-dimethoxy-penicopeptide A (2) and seven known compounds were isolated from the fermentation. Their structures were characterized by using 1D and 2D NMR techniques and MS spectrometry methods. The antibacterial effects of the isolated compounds were evaluated and the results showed compound 2 exhibited moderate antimicrobial activities against Bacillus subtilis.