Cyrhetrenyl and cymantrenyl N-acylhydrazone complexes based on isoniazid: Synthesis, characterization, X-ray crystal structures and antitubercular activity evaluation

•Synthesis of isoniazid group linked to cyrhetrenyl and cymantrenyl N-acylhydrazones.•All the complexes were fully characterized by conventional spectroscopic techniques.•The antitubercular activity against the strain H37Rv was assessed for all the complexes and organic analogs.•Organometallic derivatives with R1 = Me were more potent than their analogs with R1 = h.•The most promising compounds (R1 = Me) exhibited a cytotoxic profile similar to the RIF control.