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The landscape of the immunoglobulin repertoire in endemic pemphigus foliaceus.

Verónica Calonga-Solís,Michael Olbrich,Fabian Ott,Gabriel Adelman Cipolla,Danielle Malheiros,Axel Künstner,Ticiana D J Farias,Carolina M Camargo,Maria Luiza Petzl-Erler,Hauke Busch,Anke Fähnrich,Danillo G Augusto

Frontiers in immunology（2023）

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Abstract
Our results indicate that environmental factors, in addition to disease state, impact the characteristics of the repertoire. Our findings can be applied to further investigation of the environmental factors that trigger pemphigus and expand the knowledge for identifying new targeted and more effective therapies.
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Key words
autoimmunity,immunoglobulin repertoire,environmental factors,B cells,skin disease,pemphigus foliaceus
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