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Order from disorder in the sarcomere: FATZ forms a fuzzy complex and phase-separated condensates with alpha-actinin

Antonio Sponga,Joan L. Arolas,Thomas C. Schwarz,Cy M. Jeffries,Ariadna Rodriguez Chamorro,Julius Kostan,Andrea Ghisleni,Friedel Drepper,Anton Polyansky,Euripedes De Almeida Ribeiro,Miriam Pedron,Anna Zawadzka-Kazimierczuk,Georg Mlynek,Thomas Peterbauer,Pierantonio Doto,Claudia Schreiner,Eneda Hollerl,Borja Mateos,Leonhard Geist,Georgine Faulkner,Wiktor Kozminski, Dmitri I. Svergun,Bettina Warscheid,Bojan Zagrovic,Mathias Gautel,Robert Konrat,Kristina Djinovic-Carugo

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES（2021）

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Key words
striated muscle Z-disk, alpha-actinin, FATZ, protein-protein interaction hub, intrinsic disorder, tight fuzzy complex, liquid-liquid phase separation, integrative structural biology
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