Synthesis and Prediction of Antitumor Activity of New Fused Pyrano[3,4- c ]pyridines and Pyrano[4′,3′:4,5]pyrido[2,3- d ]pyrimidines
Russian Journal of General Chemistry(2022)
Abstract
One-pot methods were developed for the preparation of 6-amino-3-isopropyl-7-aryl substituted-8-thioxo(oxo)pyrano[3,4- c ]pyridines derivatives. The latter served as starting materials for the synthesis of a new pyrano[4′,3′:4,5]pyrido[2,3- d ]pyrimidine heterosystems. The proposed mechanisms of one-pot reactions were presented. Antitumor activity of new synthesized compounds was predicted by in silico methods.
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Key words
one-pot method, thioxo(oxo)pyrano[3,4-c]pyridine, pyrano[4′,3′:4,5]pyrido[2,3-d]pyrimidine, antitumor activity, molecular docking
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