Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Xuetong Wang,Yin Wang,Xiaoling Liu,Tingshu He,Lingli Li,Huili Wu,Shangjun Zhou,Dan Li,Siwei Liao,Ping Xu, Xing Huang,Jianyong Yuan

TETRAHEDRON（2021）

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摘要

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives. (C) 2021 Elsevier Ltd. All rights reserved.

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Imidazole hydrochloride, 1,2,4-Oxadiazole, DMA derivatives

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