LSC-2021-The relationship between the level of C-reactive protein and the general cardiovascular risk in patients with COPD and hypertension

Background: Arterial hypertension (H) is the most common comorbidity in COPD. An increase in the level of C-reactive protein (CRP) is associated with an increase in cardiovascular risk (CVR) in patients with H. The aim of the study was to identify the relationship between the level of CRP and the total 10-year (tCVR) in stable comorbid patients with COPD and H. Materials and methods: The study included 83 patients. Group I (I) - 42 stable patients with COPD with H stage II, group II (II) - 41 patients with H stage II. The calculation of the tCVR, determination of CRP (enzyme-linked immunosorbent assay), spirometry was carried out. Results: In I the average age (56.0 ± 6.7) years, the tCVR was 5.92[2.58; 10.61]%. Average age in II - (56.9 ± 5.8), total CVR - 5.85 [2.18; 11.48]%. The CRP in I (5.61 [2.55; 10.81] mg /l) was higher than in II (3.67 [1.44; 5.30]), p=0.048. In I the CRP had a negative correlation with the FEV1/FVC (R = -0.50, p=0.001). The CRP in patients of I with FEV1=50% (3.6 [1.55; 10.8] mg/l) did not differ from II, but was significantly lower than in patients with FEV1 Conclusions: Increased CRP level in stable comorbid patients with COPD and H is predominantly due to brochoobstruction.While in H, an increase in CBR has a direct relationship with the index of tCVR, in stable patients with comorbidity of COPD and H such a relationship was established only in patients with FEV1 = 50%.