Spatially-explicit modeling framework for predicting the dose-dependent effects on contraction of myotropes
BIOPHYSICAL JOURNAL(2022)
Abstract
Myotropes, such as omecamtiv mecarbil and mavacamten, are new therapeutics that bind to sarcomeric proteins. Their clinical development has reinforced the need for new quantitative understanding of sarcomere-level function.
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Key words
effects,spatially-explicit,dose-dependent
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