Decrypting nanoscale chromatin architecture alterations implicated in neuroblastoma transformation by optical nanoscopy

Higher-order spatial organization of the genome into chromatin domains is crucial for physiological cellular functioning and the onset of many diseases. Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and is characterized by remarkable heterogeneity. The molecular mechanisms involved in NB are still partially unknown, but the disruption of the