Visible‐Light‐Driven Base‐Promoted Radical Cascade Difluoroalkylation‐Cyclization‐Iodination of 1,6‐Enynes with Ethyl Difluoroiodoacetate

A visible‐light‐driven base‐promoted radical cascade difluoroalkylation/5‐exo‐dig cyclization/iodination of 1,6‐enynes with ethyl difluoroiodoacetate was developed under catalyst‐free and oxidant‐free conditions. The difluoroalkylated pyrrolidines and tetrahydrofuran derivatives were generated with good functional group tolerance and high Z/E stereoselectivity. This reaction provided an alternative and mild method for the preparation of highly functionalized and vinyl C−I bonds containing five‐membered heterocyclic products.