Langerhans cell histiocytosis developing acute lymphoblastic leukemia
SAGE OPEN MEDICAL CASE REPORTS(2022)
摘要
The sequential occurrence of Langerhans cell histiocytosis and acute leukemia in only one individual has been reported previously; however, it is rarely observed that Langerhans cell histiocytosis can transform into acute lymphoblastic leukemia, and the underlying mechanisms remain unclear. In this report, we have analyzed a case of acute lymphoblastic leukemia converted from Langerhans cell histiocytosis using high-throughput sequencing method, and found that mitogen-activated protein kinase gene mutation, which can act as a marker for poor prognosis, might be involved in disease transformation. This is the first description about acute lymphoblastic leukemia B-cell type after Langerhans cell histiocytosis diagnosis and therapy in China.
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关键词
Langerhans cell histiocytosis, acute lymphocytic leukemia, high-throughput sequencing, transformation
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