Sodium Cefotaxime–Potato Starch Conjugate as a Potential System for Antibacterial Drug Delivery

Sodium cefotaxime in a polymeric matrix of the periodate oxidation product of potato starch (68 mol% content of CHO groups) was synthesized. Formation of the conjugate was confirmed by IR and UV spectroscopy. PMR spectroscopy found that the degree of conjugation was 30 mol%. The antibiotic was released from the synthesized conjugate via cleavage of the azomethine bond in various biorelevant media slower than cefotaxime was eliminated from the body if the traditional dosage form was used.