METABOLOMICS OF OSTEOARTHRITIS WITH SYNOVITIS IN MIDDLE AGED WOMEN FROM THE IWAKI HEALTH PROMOTION PROJECT

Purpose: Osteoarthritis (OA), an age-related low-grade inflammatory disease of the synovial joints, is one of the costliest and most disabling forms of arthritis. Although prevention and an early diagnosis are prerequisites for a favorable outcome, the detailed etiology, pathophysiology, and metabolism remain unclear. Recent omics profiling approaches combined with clinical measures comprehensively assess the health status and identify deviations; metabolomics can detect many small-molecule metabolites in body fluids or tissues in a single step.