Non-linear interaction between two inputs depending on an intrinsic factor in hippocampal granule cells

To investigate the role of the nonlinearity of input interactions in the neural network, we examined the influence of acetylcholine as a top-down input on the interaction between bottom-up inputs in dentate granule cells in the hippocampus. The results showed that nonlinearity in the interaction between bottom-up inputs was modulated by the top-down input and was related to inhibitory cells. Our findings suggest that nonlinearity in the interaction of inputs plays a key role in coincidence detection, which is regulated by the top-down input. This indicates a crucial role for nonlinearity in the neurodynamics of the hippocampal local network.