Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy
Nano Research(2022)
摘要
Thylakoid (Tk) membranes are of unique superiority in photodynamic therapy (PDT) because they not only carry abundant chlorophylls containing photosensitizer porphyrin but also can produce O 2 . However, the current therapeutic performance of Tk is dramatically limited because of their poor tumor targeting and inefficient O 2 production. Here, we report an immunomodulatory bio-nanovesicle of Tk membranes fused with M1 macrophage-derived extracellular vesicles (M1 EV) for efficient PDT of tumors. The hybrid nanovesicle Tk@M1 was prepared by squeezing the Tk membranes of spinach with M1 EV. The systemic study confirmed that Tk@M1 can not only actively accumulate in tumors but also effectively regulate the inactive immune microenvironment of tumors. Such activated “hot” tumors significantly enhance the PDT efficacy of Tk@M1 attributed to the increased O 2 from catalase catalyzed decomposition of augmented H 2 O 2 , providing a novel idea about constructing natural systems for effective tumor treatment.
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关键词
thylakoid,photodynamic therapy,extracellular vesicle,M1 macrophage,immunomodulation
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