Synthesis of New 6-Oxo-1,6-Dihydropyrimidin-5-Carboxamides and Evaluation of Their anti-Bacterial and anti-Oxidant Activities

A new series of 6-oxo-1,6-dihydropyrimidin-5-carboxamides (4a-m) has been synthesized and reported with good yields. All these compounds were characterized using various spectral techniques such as IR, H-1 NMR, C-13 NMR, and HRMS and then subjected to in-vitro anti-oxidant and anti-bacterial activities using DPPH and microdilution methods, respectively. Among the synthesized pyrimidine-5-carboxamides, compounds 4a-b, 4j, and 4i were found to exhibit promising antibacterial activity compared to the standard drug Neomycin. Similarly, compounds 4g-i and 4l displayed excellent anti-oxidant activities against the standard drug ascorbic acid.