Synthesis of Ethyl 4-[5-Aryl-3-hydroxy-4-(4-chlorobenzoyl)-2-oxo-2,3-dihydro-1 H -pyrrol-1-yl]benzoates

V. L. Gein, D. A. Naif,E. V. Pastukhova,I. P. Yakovlev

RUSSIAN JOURNAL OF GENERAL CHEMISTRY（2021）

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摘要

The reaction of (4-chlorobenzoyl)pyruvic acid methyl ester with a mixture of aromatic aldehyde and 4-aminobenzoic acid ethyl ester in glacial acetic acid afforded ethyl 4-[5-aryl-3-hydroxy-2-oxo-4-(4-chlorobenzoyl)-2,5-dihydro-1 H -pyrrol-1-yl]benzoates.

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关键词

ethyl 4-[5-aryl-3-hydroxy-2-oxo-4-(4-chlorobenzoyl)-2,5-dihydro-1H-pyrrol-1-yl]benzoates,ethyl 4-aminobenzoate,benzocaine (anesthesine),tetrahydropyrrole-2,3-diones,three-component reactions

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