Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents

Purna Koteswara Rao Cherukumalli,Bhaskara Rao Tadiboina,Kali Charan Gulipalli,Srinu Bodige,Vishnu Nayak Badavath,Gattu Sridhar,Kiran Gangarapu

Journal of Molecular Structure（2022）

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摘要

•A series of novel urea derivatives of pyrimidine-pyrazole were synthesized.•Synthesized compounds were screened for anti cancer activity.•Compounds 12b, 12c, 12d, 12g and 12h exhibited more potent activity.

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关键词

Urea derivatives,Pyrimidine-pyrazoles,Anticancer activity,Tubulin protein inhibitors,Molecular docking studies

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