Copper-Catalyzed Cross-Coupling of Arylacetylenes with Bromodifluoroacetamides
SYNLETT(2022)
摘要
AbstractA copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system.
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关键词
copper catalysis, arylacetylenes, bromodifluoroacetamides, cross-coupling, difluoroalkylation
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