Antibacterial activity and acute toxicity study of standardized aqueous extract of Randia monantha Benth fruit

The fruit of Randia monantha, traditionally and empirically used in the preparation of a beverage as antivenom and for the treatment of various diseases has little scientific evidence regarding its antimicrobiological properties and toxicity. The objective of this study was to evalute the antimicrobial effect of the Randia monantha pulp aqueous extract on acute toxicity in male Wistar rats, evaluated at different concentrations against pathogenic bacteria. The results of acute oral toxicity revealed no deaths with doses up to 5000 mg/kg body weight. The experimental animals showed no significant changes in the weight and behavior parameters evaluated with respect to the control treatment. Rats did not show significant changes in the hematological parameters, but dosis of 5000 mg/kg body weight rats exhibited the appearance of yellow spots on kidney. The aqueous extract had no antimicrobial activity against pathogenic bacteria tested. These results suggest that the Randia monantha fruit aqueous extract can be used with some degree of safety by oral administration but should not be taken in high doses.