Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY(2021)
摘要
In this study, the influence of incorporation of gadolinium ions in CdTe quantum dots lattice on the biodistribution of [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles was investigated. [ 68 Ga] Ga@Gd-CdTe QDs nanoparticles were prepared using high purity [ 68 Ga] GaCl 3 and thioglycolic acid (TGA) capped Gd-CdTe QDs. TGA capped Gd-CdTe QDs were characterized with high resolution transmission electron microscopy (HR-TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), infrared spectroscopy (FTIR), UV–Vis spectroscopy, photoluminescence spectroscopy and vibrating sample magnetometry (VSM). The radiochemical purity and stability of the [ 68 Ga] Ga@Gd-CdTe QDs were performed using conventional instant thin layer chromatography. In-vivo biodistribution studies in rats bearing fibrosarcoma tumors were performed by intravenously injection of [ 68 Ga] Ga@Gd-CdTe QDs nanocomposite followed by positron emission tomography (PET) imaging. High (8.8%) and rapid (after 24 min) tumor uptake of [ 68 Ga] Ga@Gd-CdTe QDs were observed.
更多查看译文
关键词
[Ga-68] Ga, Gadolinium, CdTe quantum dots, Fibro sarcoma tumor, PET, MRI
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要