THEORETICAL AND EXPERIMENTAL STUDY OF MACROMOLECULAR NANOSTRUCTURES BASED ON HEPARIN AND LANTHANOIDS

Study of synthetic and natural materials suitable for the creation of nanocarriers and their modification will provide a breakthrough in the treatment of many diseases. Glycosaminoglycans (heparin and its derivatives) are a good choice for creating nanocarriers due to their unique biological and physicochemical properties. The complexation of Pr (III), Sm (III), Eu (III) with heparin anions was studied by potentiometric titration at 37 degrees C and an ionic strength of 0,15 M NaCl. Significant forms and chemical equilibria were determined using the NewDALSFEK program. In the pH range from 2, 7 to 5, a complex of the type {[LnHep]}(n) is formed, where Hep(3-) is a monomeric unit of the heparin macromolecule. Data on the stability of nanocompositions were obtained: lg beta[PrHep] = 4,27 +/- 0,04, lg beta[SmHep] = 4,28 +/- 0,03, lg beta[EuHep] = 4,28 +/- 0,03. The M06-HF method in combination with the CSDZ+* basic set was used to perform quantum chemical modeling of the complexes.