Polyaromatic ring containing β-diketone derivatives with antiproliferative activity toward human breast cancer cell lines: Synthesis, structure, DNA binding and molecular docking

Journal of Molecular Structure（2022）

引用 5|浏览1

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摘要

•Novel ketamines with extended conjugation.•Single crystal XRD, spectral and DFT studies.•In vitro cytotoxicity of L1-L4 against MCF 7 and HBL 100 cell lines.•Cellular apoptosis process through induction of ROS using DCFH-DA staining.•Molecular docking analysis with breast cancer protease 3EU7.

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关键词

β-diketone derivatives,Crystal structure,DNA binding,Cytotoxicity,ROS generation,Molecular docking

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