Toxicity and Local Irritation Action of the Biomedical Cell Product Anti-HER2-CAR-T-NK Upon Multiply Repeated Administration

N. A. Goryacheva, D. I. Rzhevskii, G. A. Slashcheva, N. I. Novikova, M. V. Kiselevskii, I. O. Chikileva,R. Ya. Vlasenko,A. N. Murashev, D. A. Bondarenko

Pharmaceutical Chemistry Journal（2022）

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摘要

CAR-cell therapy is a promising new method of cancer treatment. The biomedical cell product Anti-HER2-CAR-T-NK cells has been found safe in a course of intraperitoneal injection at a human-equivalent therapeutic dose in male and female ICR mice. The obtained information can help in the future to form the basis of recommendations for preclinical studies of CAR-cell immunopreparations.

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关键词

CAR, CAR-T, CAR-NK, chimeric antigen receptor, toxicity studies

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