Synthesis, Phosphonylation, and Anti-Viral Activity of Some 6-Aryl-5-cyano-2-thiouracils

A series of 6-aryl-5-cyano-2-thiouracils was synthesized, the reaction of which with diethyl chloroethynylphosphonate leads to the selective formation of new 3-phosphonylated thiazolo[3,2- a ]pyrimidines. For the starting 6-aryl-5-cyano-2-thiouracils and their phosphonylated derivatives, antiviral activity against influenza A (H 1 N 1 ) virus and cytotoxicity were studied.