DBU-catalyzed Michael addition of bulky glycine imine to α,β-unsaturated isoxazoles and pyrazolamides
TETRAHEDRON（2021）
Abstract
DBU-catalyzed Michael additions of bulky glycine imines to α,β-unsaturated isoxazoles and pyrazolamides have been realized in THF with 1.0 eq. LiBr as an additive at room temperature to provide Michael adducts in excellent yields (up to 97%) and diastereoselectivities (> 20:1).Image 1
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Key words
Michael addition,Glycine imine,α,β-unsaturated isoxazole,α,β-unsaturated pyrazolamide,1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)
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