SYNTHESIS OF TRIFLUOROMETHYL DERIVATIVES OF QUINOLINE AND ISOQUINOLINE

Aki Fujisaka, Daiki Aomatsu, Yoichiro Kakutani, Ryuya Terai, Kumiko Sakaguchi,Masahiro Ikejiri,Kazuyuki Miyashita

HETEROCYCLES（2022）

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摘要

Trifluoromethyl derivatives of quinoline and isoquinoline were synthesized using phosphonium salts with a trifluoroacetamide group in the presence of 1,8-diazabicyclo[5.4.0]-7-undecene. The quinoline skeleton was formed from a phenethylphosphonium salt with a trifluoroacetamide NH proton, whereas the isoquinoline formation required masking of the amide proton of trifluoroacetamide in the benzylphosphonium structure.

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