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S. aureus Superantigens found on AD Skin Alter Human Keratinocyte Biology

Mary Moran,Matthew Brewer,Patrick Schlievert,Michael Cahill,Takeshi Yoshida,Brian Ward,Steven Gill,Lisa Beck

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY（2022）

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Abstract
Patients with atopic dermatitis (AD) have an altered skin microbiota with elevated S. aureus abundance and experience increased cutaneous viral infections. We hypothesize that S. aureus superantigens (SAgs) alter epithelial cell biology in ways that enhance keratinocyte susceptibility to viral infections.
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