Studying the Role of DNA Repair Gene Polymorphism in Formation of Predisposition to Lung Cancer Development in Women

The study involved 522 women of Russian nationality living in Kemerovo oblast of Russia, including 273 patients with lung cancer and 249 women of a similar age with no signs of cancer. Comparative analysis of polymorphic variants of DNA repair genes APEX1 444T>G (rs1130409), XRCC1 1839G>A (rs25489), hOGG1 977C>G (rs1052133), XPD 2251Т>G (rs13181), XPG 3310G>C (rs17655), and XPC 2815A>C (rs2228001) in patients with lung cancer and individuals without cancer living in the same area was performed. Analysis of single-locus effects showed significant associations between the risk of lung cancer and variants of the XPC 2815A>C gene (rs2228001) (OR = 0.56, CI: 0.39–0.81, p = 0.0018) in the general group, the APEX1 444T>G gene (rs1130409) (OR = 0.15, CI: 0.03–0.67, p = 0.0027) in the group of smokers, and genes XPC 2815A>C (rs2228001) (OR = 0.36, CI: 0.18–0.69, p = 0.0051) and hOGG1 977C>G (rs1052133) (OR = 0.57, CI: 0.38–0.85, p = 0.0055) in the group of nonsmokers. MDR analysis of gene-gene interactions showed that genes XPD 2251Т>G and XPC 2815A>C, APEX1 444T>G, and XPD 2251Т>G closely interact and mutually increase the risk of lung cancer in women of Western Siberia.