Sustainable synthesis of potential antitumor new derivatives of Abemaciclib and Fedratinib via C-N cross coupling reactions using Pd/Cu-free Co-catalyst

•Synthesis and characterization of novel cobalt-based magnetic silica nanocomposite.•Efficient performance of C-N cross-coupling reactions in green and mild reaction conditions.•Synthesis of new derivatives of Abemaciclib and Fedratinib for the first time as potential antitumor agents with excellent yields.•Close interaction of synthesized compounds with related protein in comparison with main approved drugs, studied by molecular docking method.