Peculiarities of Solubility and Cytocompatibility In Vitro of Bone Cements on the Basis of Calcium Sulfate Containing Phosphate Ions

Cement materials based on calcium sulfate into which up to 20 mol % of phosphate groups were introduced were obtained in order to improve their cytocompatibility and solubility. It was found that, during exposure of cement materials on the basis of calcium sulfate containing 0, 5, 10, and 20 mol% phosphate groups in model Kokubo solution (simulated body fluid (SBF) simulating the composition of human blood plasma) and Dulbecco’s phosphate-buffered saline (DPBS), the formation of a calcium phosphate layer on the surface of the samples was observed in dynamics up to 28 days. In this case, the process of recrystallization of sulfate and phosphate phases was more pronounced in SBF than in DPBS. In in vitro studies on the MG-63 human osteosarcoma line cell culture, cement samples showed cytocompatibility with the presence of moderate matrix surface properties.