Synthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases

A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via H-1 and C-13 NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d, 12g and 121 demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 - 62.5 mu g/mL. Further, compounds 12d, 12g and 121 exhibit promising antifungal activity with MIC values ranging between 7.8 - 32.5 mu g/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.