COPPER CORROLE CATALYZED ESTERIFICATION OF C(sp(3))-H WITH CARBOXYLIC ACIDS VIA CROSS-DEHYDROGENATIVE COUPLING REACTION

Copper corrole complex was firstly used as catalyst for oxidative esterification of un-reactive C(sp(3))-H bond of cyclic ether and carboxylic acid via cross-dehydrogenative coupling (CDC) reaction using di-tert-butyl peroxide (DTBP) as oxidant. A wide range of carboxylic acids can react with cyclic ether with good to excellent yields, showing copper corrole is a new kind of promising catalyst for CDC reaction. Under gram-level test, the turnover number (TON) may achieve 8400 with 84% yield at only 0.01% catalyst loading, demonstrating its practical uses.