Identification of 1,3-thiazinan-4-one urea-based derivatives as potent FLT3/VEGFR2 dual inhibitors for the treatment of acute myeloid leukemia

•Novel 1,3-thiazinan-4-one urea analogues were designed and synthesized.•Compound 4f was identified as a potential FLT3/VEGFR2 dual inhibitor.•Compound 4f exhibited over 41-fold selectivity toward FLT3 relative to c-Kit.•Compound 4f possessed significantly inhibitory activities against MV4-11 cells.