X-Ray diffraction structure of Cu(II) and Zn(II) complexes of 8-aminoquinoline derivatives (TDMQ), related to the activity of these chelators as potential drugs against Alzheimer's disease

•TDMQ, regulators of copper homeostasis as drug-candidates against Alzheimer's disease.•The definition of the coordination sphere of TDMQ chelators is crucial for regulation of Cu homeostasis.•A N4-square planar X-ray structure of Cu-TDMQ complexes is required.•Specificity of TDMQ ligands for Cu(II) with respect to low affinity for Zn(II).