Synthesis of 3-substituted tetrahydroindol-4-one

series of functionalized 4,5,6,7-tetrahydroindol-4-one derivatives containing a residue derived from β-dicarbonyl compound at position 3 were prepared by a reaction of cyclic enaminones, arylglyoxal hydrates, and β-dicarbonyl compounds. Modification of acetylacetone residue at position 3 of tetrahydroindoles was accomplished by condensation with 1,2- and 1,4-bisnucleophiles.