Preparation and Mechanism of the Antitumor Action of a 4 H -Aminochromene Compound

We report here studies of the antitumor action of a 4 H -aminochromene compound in a xenograft model of ALK-expressing lung adenocarcinoma in humanized nude BALB/c mice. These studies showed that intragastric administration of the compound produced dose-dependent reductions in tumor size and metastasis frequency, with increases in the survival of xenograft-carrying animals. The effect of the compound is based on suppression of the expression of receptor tyrosine kinase and β3-tubulin in tumor tissues and activation of caspase-3-dependent programmed tumor cell death. The results allow the 4 H -aminochromene compound AKh-554 to be regarded as having potential for development of molecularly targeted drugs.