Prognostic value of galectin-1 and galectin-3 expression in local urothelial bladder cancer.

Jason Zhu,Chad Livasy,Erin E. Donahue,James Thomas Symanowski,Claud Grigg,Justin T. Matulay,James T. Kearns,Derek Raghavan,Earle F. Burgess,Peter E. Clark

JOURNAL OF CLINICAL ONCOLOGY（2021）

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摘要

Gal-1 and Gal-3 H-score per bladder did not independently predict for RFS or OS. Intra-tumoral Gal-1/Gal-3 heterogeneity complicates the use of Gal-1 and Gal-3 expression as a prognostic biomarker. Future studies should consider the evaluation of serum and urinary galectins as an approach to mitigate tumor heterogeneity.

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关键词

(Gal-3) urothelial carcinoma,Galectin-1 (Gal-1),galectin-3,tumor heterogeneity

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