A New Method for Detecting Environmental Pollutant Sodium Pentachlorophenate (PCP-Na) Based on PAX Solid-Phase Extraction and UPLC-MS/MS

Pentachlorophenol (PCP) and sodium pentachlorophenate (PCP-Na) are both organochlorine pesticides. Excessive use of PCP-Na can cause water and soil pollution. In this study, a new method was established to verify the residual amount of PCP-Na in samples through the combination of PAX solid-phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. The sample containing PCP-Na was extracted with acetonitrile solution and subjected to PAX anion solid-phase extraction. After eluting with acid methanol solution, the content of PCP was separated and detected on the ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The method has good detection performance in the PCP-Na at the concentration range of 1–20 ug/L, and the experimental method is simple to operate and accurate. The result shows that different types of solid extraction impact the detection ability of PCP-Na. Using a suitable extraction column can effectively reduce the impact of impurities on the detection of PCP-Na. The ceramic homogenizer addition can make the recovery rate of PCP-Na in the test sample higher. The recovery rate of PCP-NA of frozen-extracted samples is higher than that of samples that have not been frozen-extracted. It is recommended that samples processed under frozen-extracted and ceramic homogenizer addition can obtain better separation results.