Miscibility and thermal stability of synthetic glutamic acid comprising polypeptide with polyvinyl alcohol: Fabrication of nanofibrous electrospun membranes

In this work, the novel glutamic acid-containing polypentapeptide, poly[0.8(AVGVP),0.2(AEGVP)] (where A-Alanine, V-Valine, G-Glycine, E-Glutamic acid, and P-Proline), was synthesized and generated the thin membranes with polyvinyl alcohol (PVA). The viscometric parameters registered that two polymers were miscible up to 30% of the polypentapeptide in the blend. DSC analysis showed a single Tg (glass transition temperature), distinctive of a miscible mixture. The depth of inter associative interplays depends reasonably on the formation of hydrogen bonds, as demonstrated in FTIR (Fourier transform infrared) spectroscopy. TGA (Thermogravimetric analysis) attested to the uppermost thermal stability of miscible combinations against immiscible blends. Besides, the SEM and X-Ray Diffraction study validated the outcomes. Furthermore, electrospinning of the miscible blends produced the membranes. Also, the consequent non-woven mats may aid in the advancement of alternative biomaterials with novel peculiarities.